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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Radix ranunculus temate saponins, Paclitaxel
Phytochemical Name Radix ranunculus temate saponins (PubChem CID: / )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 205
Ref_1
Pair Name Radix ranunculus temate saponins, Paclitaxel
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Gene Regulation Down-regulation Expression COL3A1 hsa1281
In Vitro Model A2780 Ovarian endometrioid adenocarcinoma Homo sapiens (Human) CVCL_0134
OVCAR-3 High grade ovarian serous adenocarcinoma Homo sapiens (Human) CVCL_0465
SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_0532
In Vivo Model A2780 cells (1×10⁶) were injected subcutaneously into the back of six-week-old BALB/c nu/nu female mice.
Result Combination of Taxol and RRTS may be a novel treatment strategy for patients with TR ovarian cancer.
03. Reference
No. Title Href
1 Radix ranunculus temate saponins sensitizes ovarian cancer to Taxol via upregulation of miR-let-7b. Exp Ther Med. 2022 May;23(5):315. doi: 10.3892/etm.2022.11244. Click
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